GSE34989   Details

GSE Accession GSE34989
Title Survey gene expression profiles and patterns between the four cell types (CD133+, CD133+CD31+, CD31+, heterogeneous population) of IH cells
Submission Date 1/10/12
Last Update Date 12/6/12
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Experiment Type Expression profiling by array
Contributor Shaghayegh,,Harbi
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Organism Homo sapiens
Organism ID 9606
Organism Synonym man; human
Summary To further development of gene expression signatures for infantile hemangioma cells, gene expression analysis was performed of different human cell samples using Agilent whole human genome oligo microarrays. The purpose of the experiments are: a) to identify the intrinsic differences between HemSc and HemEc and compare HemSc and HemEc genetically; b) analyze the “stemness” genes, paracrine/endocrine associated genes (”angiocrine”), and genes that regulate development, vasculogenesis and immunity; c) identify involvement of the signaling pathways at various stages of differentiation; d) provide new perspectives on the failure of anti-vasculogenic inhibitors currently in use.
Overall Design Expression Profiles: To employ whole human genome gene expression analysis of infantile hemangioma cells by using microarray analysis followed by qRT-PCR to: a) survey gene expression profiles and patterns between the four cell types (CD133+, CD133+CD31+, CD31+, heterogeneous population; b) to survey gene expression profiles and patterns of the HemScs and the heterogeneous population following exposure to dexamethasone for studies for exposure to drug at 2 timepoints (+2 hours (h) post exposure/+22 hours (h) post exposure).
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