GSE33798   Details

GSE Accession GSE33798
Title Of Mice and Men: Commonality and Disparity in the Murine and Human Response to Burn Injury
Submission Date 11/18/11
Last Update Date 12/12/13
Pubmed ID
Experiment Type Expression profiling by array; Third-party reanalysis
Contributor Alex,G,Cuenca; Lori,F,Gentile; Lopez M. Cecilia; Richard,L,Gamelli; Shankar Ravi; Celeste,C,Finnerty; Daniel,G,Remick; Lyle,L,Moldawer; David,N,Herndon; Henry,V,Baker
Contact Name
Contact E-mail
Organization Name
Country
Organism
Organism ID
Organism Synonym
Summary Gene expression comparison of burns in young mice and male pediatric patients. This paper examines changes in gene expression from whole blood leukocytes in response to burn injury, and compares burn responsive genes in the human to those in the mouse, as reported by Lederer et al. (Lederer et al., 2008).
Overall Design Test whether mouse model can recapitulate the human burn injury.; ; Seventy-seven male burn patients, ages 0-17 years, were recruited at the University of Texas Medical Branch (Galveston, TX) as approved by the Institutional Review Board, and enrolled into the federally funded, Inflammation and Host Response to Injury program between the years 2003-2009. Eligible subjects had burns greater than 20% of total body surface TBSA, and requiring at least one excision and grafting procedure. Twelve healthy male subjects between the ages of 0-17 years with a similar age distribution made up the control group.
Platform ID
Timepoint Count 0
Timepoints
Disease
Disease ID