GSE32053   Details

GSE Accession GSE32053
Title FoxO3a drives a regulatory network associated with therapeutic response in metastatic prostate cancer
Submission Date 9/12/11
Last Update Date 8/1/13
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Experiment Type Expression profiling by array
Contributor Carolyn,,Waugh Kinkade; Alvaro Aytes; Celine Lefebvre; Antonina Mitrofanova; Ladan Fazli; Vanessa Biggs; H Le; Jason,A,Koutcher; Kenneth,J,Pienta; Robert,D,Cardiff; Martin,E,Gleave; Michael Shen; Andrea Califano; Cory Abate-Shen
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Summary Anaysis of the response to different therapeutic agents at the transcriptional level. The design of the experiment allows to determine how the combination target therapy (Rapamycin + PD0325901) treatment shifts the transcriptome towards a less aggressive or even a wild type phenotype more efficiently than conventional chemotherapy (Docetaxel). It also allows exploring the molecular chages involved in the transition from a non metastatic to a metastatic prostate cancer mouse model.
Overall Design Total RNA obtained from prostate tumors or wild type prostate after treatment with targeting agents compared to chemotherapy and/or vehicle as indicated
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