GSE129486   Details

GSE Accession GSE129486
Title Transcriptional responses of human synovial fibroblasts to TNF and IL-17A over time (RNA-seq Data 1)
Submission Date 4/8/19
Last Update Date 6/2/19
Pubmed ID
Experiment Type Expression profiling by high throughput sequencing
Contributor Kamil,,Slowikowski; Hung,N,Nguyen; Erika,H,Noss; Daimon,P,Simmons; Fumitaka Mizoguchi; Gerald,F,Watts; Michael,F,Gurish; Michael,B,Brenner; Soumya Raychaudhuri
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Organism Homo sapiens
Organism ID 9606
Organism Synonym man; human
Summary The combination of TNF and IL-17A has synergistic effects on the transcription of genes encoding chemokines and cytokines.
Overall Design Human fibroblasts derived from individual with rheumatoid arthritis or osteoarthritis were stimulated with TNF or TNF and IL-17A and gene expression was assayed with RNA-seq.; ; RNA-seq Data 1 (n=175): 7 synovial fibroblast cell lines from patient tissues, 9 time points (0, 2, 4, 6, 8, 10, 12, 18, and 24 hours), 3 stimulations (TNF (1 ng/mL); TNF (1 ng/mL) and IL-17A (1 ng/mL); TNF (1 ng/mL) and IL-17A (10 ng/mL)).; ; ---------------------------------------------------------------; Authors state "We don't have the required patient consents to deposit the raw sequencing reads."; Thus, this dataset is incomplete.
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Timepoint Count 175
Timepoints gsm: [1 time-, 10 time-, 100 time-, 101 time-, 103 time-, 104 time-, 105 time-, 106 time-, 107 time-, 108 time-, 109 time-, 11 time-, 111 time-, 112 time-, 113 time-, 114 time-, 115 time-, 116 time-, 117 time-, 119 time-, 12 time-, 120 time-, 121 time-, 122 time-, 123 time-, 124 time-, 125 time-, 127 time-, 128 time-, 129 time-, 13 time-, 130 time-, 131 time-, 132 time-, 133 time-, 135 time-, 136 time-, 137 time-, 138 time-, 139 time-, 140 time-, 141 time-, 143 time-, 144 time-, 145 time-, 146 time-, 147 time-, 148 time-, 149 time-, 15 time-, 151 time-, 152 time-, 153 time-, 154 time-, 155 time-, 156 time-, 157 time-, 159 time-, 16 time-, 160 time-, 161 time-, 162 time-, 163 time-, 164 time-, 165 time-, 167 time-, 168 time-, 169 time-, 17 time-, 170 time-, 171 time-, 172 time-, 173 time-, 175 time-, 176 time-, 177 time-, 178 time-, 179 time-, 18 time-, 180 time-, 181 time-, 183 time-, 184 time-, 185 time-, 186 time-, 187 time-, 188 time-, 189 time-, 19 time-, 191 time-, 192 time-, 193 time-, 194 time-, 195 time-, 196 time-, 197 time-, 199 time-, 2 time-, 20 time-, 200 time-, 21 time-, 23 time-, 24 time-, 25 time-, 26 time-, 27 time-, 28 time-, 29 time-, 3 time-, 31 time-, 32 time-, 33 time-, 34 time-, 35 time-, 36 time-, 37 time-, 39 time-, 4 time-, 40 time-, 41 time-, 42 time-, 43 time-, 44 time-, 45 time-, 47 time-, 48 time-, 49 time-, 5 time-, 50 time-, 51 time-, 52 time-, 53 time-, 55 time-, 56 time-, 57 time-, 58 time-, 59 time-, 60 time-, 61 time-, 63 time-, 64 time-, 65 time-, 66 time-, 67 time-, 68 time-, 69 time-, 7 time-, 71 time-, 72 time-, 73 time-, 74 time-, 75 time-, 76 time-, 77 time-, 79 time-, 8 time-, 80 time-, 81 time-, 82 time-, 83 time-, 84 time-, 85 time-, 87 time-, 88 time-, 89 time-, 9 time-, 90 time-, 91 time-, 92 time-, 93 time-, 95 time-, 96 time-, 97 time-, 98 time-, 99 time-]
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